Connie H. Miller, Ph.D.
Director, Hemostasis Laboratory
Hematologic Diseases Branch, NCID/DASTLR
Centers for Disease Control and Prevention
Address
1600 Clifton Road,
Mailstop D02, Atlanta, GA 30333
Telephone: (404)
639-2851 FAX: (404) 639-1638
E-mail: crm5@cdc.gov
Education
Ph.D., Genetics, 1977
University of North
Carolina, Chapel Hill
Bachelor of Science,
Biology, 1972
East Texas State
University, Commerce, Texas
Hendrix College,
Conway, Arkansas, 1968-1970
Certification
Ph.D. Medical
Geneticist, 1982, American Board of Medical Genetics
Positions Held
January 1999- Director,
Hemostasis Laboratory
Present
Hematologic Diseases Branch
Division
of AIDS, STD, and TB Laboratory Research
National
Center for Infectious Diseases
Centers
for Disease Control & Prevention
Atlanta,
Georgia
October 1992- Associate Professor of
Pediatrics, Division of Hematology/Oncology,
January 1999 Northwestern University Medical
School, Chicago, Illinois
Director,
Coagulation Laboratory
Children’s
Memorial Hospital, Chicago, Illinois
Administrative Director, Comprehensive Hemophilia
Treatment Center
Children’s
Memorial Hospital, Chicago, Illinois
Geneticist, Comprehensive
Hemophilia Treatment Center
Children’s
Memorial Hospital, Chicago, Illinois
August 1986- Associate
Professor of Pediatrics and Pathology
September 1992 University of Arkansas for Medical
Sciences, Little Rock, Arkansas
Director,
Clinical Coagulation Laboratory
Arkansas
Children’s Hospital, Little Rock, Arkansas
Clinical
Director, Maternal Serum AFP & hCG Screening Program
University
of Arkansas for Medical Sciences, Little Rock, Arkansas
Co-Director, Arkansas Genetics Program
Arkansas
Children’s Hospital and University of Arkansas for
Medical Sciences
September 1983- Assistant Professor of Medicine and
Pediatrics
July 1986 Divisions of
Hematology and Genetics
Mount
Sinai School of Medicine, New York, New York
Director,
Special Coagulation Laboratory
Mount
Sinai Medical Center, New York, New York
Geneticist, Regional Hemophilia Diagnostic and Treatment
Center
New York
Hospital-Cornell University Medical Center and Mount
Sinai Medical Center, New York, New York
September 1977- Assistant
Professor of Genetics, Department of Pediatrics
August 1983 Cornell University Medical College, New
York, New York
Director, Special Coagulation
Laboratory
New York Hospital-Cornell
University Medical Center, New York, New York
Geneticist, Regional Hemophilia Diagnostic
and Treatment Center
New York
Hospital-Cornell University Medical Center and Mount
Sinai Medical Center, New York, New York
September 1976- National Institutes of Health
Graduate Fellow, Curriculum in Genetics
August 1977 University of North Carolina, Chapel Hill
September 1972- National
Science Foundation Graduate Fellow, Curriculum in
Genetics
August 1976 University of North Carolina, Chapel Hill
Professional Activities
1998-Present Member,
International Subcommittee on von Willebrand Factor
International Society on Thrombosis and Haemostasis
1987-1992 Member, Sickle Cell
Advisory Committee
Newborn
Screening Program, Arkansas Department of Health
1987-1992 Member, DNA
Diagnostics Committee
Great
Plains Genetic Services Network
1985-1986 Member,
Institutional Review Board, CDC AIDS Project
National
Hemophilia Foundation
1983-1986 Chair, Laboratory Task Force
Region II
Hemophilia Treatment Centers
1983-1986 Member, Hemophilia
Advisory Panel
New York
State Department of Health
1979-1986 Member, Executive Committee
New York
State Genetic Diseases Program
New York
State Department of Health, Albany, New York
1979-1986 Project Coordinator,
Statewide Hemophilia Counseling Services
New York
State Genetic Diseases Program
Professional Organizations
American Society of
Hematology
International Society
on Thrombosis and Haemostasis
World Federation of
Hemophilia
Publications
Articles
1. Elston RC, Graham JB, Miller CH, Reisner HM,
Bouma BN. Probabilistic classification of hemophilia A
carriers by discriminant analysis. Thrombosis Research
8: 683-695, 1976.
2. Graham JB, Miller CH, Reisner HM, Elston RC,
Olive JA. The phenotypic range of hemophilia A
carriers. American Journal of Human Genetics 28:
482-488, 1976.
3. Edgell CJS, Kirkman HN, Clemons E, Buchanan
PD, Miller CH. Prenatal diagnosis by linkage:
hemophilia A and polymorphic glucose-6-phosphate
dehydrogenase. American Journal of Human Genetics 30:
80-84, 1978.
4. Miller CH, Graham JB, Goldin LR, Elston RC.
Genetics of classic von Willebrand's disease. I.
Phenotypic variation within families. Blood 54:
117-136, 1979.
5. Miller CH, Graham JB, Goldin LR, Elston RC.
Genetics of classic von Willebrand's disease. II.
Optimal assignment of the heterozygous genotype
(diagnosis) by discriminant analysis. Blood 54:
137-145, 1979.
6. Guenthner EE, Hilgartner MW, Miller CH,
Vienne G. Hemophilic arthropathy: effect of home care
on treatment patterns and joint disease. Journal of
Pediatrics 97: 378-382, 1980.
7. Goldin LR, Elston RC, Graham JB, Miller CH.
Genetic analysis of von Willebrand's disease in two
large pedigrees: a multivariate approach. American
Journal of Medical Genetics 6: 279-293, 1980.
8. Nachman RL, Jaffe EA, Miller C, Brown WT.
Structural analysis of factor VIII antigen in von
Willebrand's disease. Proceedings of the National
Academy of Sciences U.S.A. 77: 6832-6836, 1980.
9. Hilgartner MW, Miller CH. Disorders of
hemostasis in pregnant patients. Contemporary Ob/Gyn
17: 55-70, 1981.
10. Miller CH, Hilgartner MW, LeStrange RC,
McLaughlin GE. Factor VIII related antigen pre-peak on
crossed immunoelectrophoresis: a non-random phenomenon.
Thrombosis Research 25: 101-107, 1982.
11. Barrow ES, Miller CH, Reisner HM, Graham JB.
Genetic counseling in haemophilia by discriminant
analysis 1975-1980. Journal of Medical Genetics 19:
26-34, 1982.
12. Miller CH, Orstavik KH, Hilgartner MW.
Characterization of an occult inhibitor to factor IX in
a haemophilia B patient. British Journal of Haematology
61: 329-338, 1985.
13. Markova I, Forbes CD, Aledort LM, Inwood M,
Mandalaki T, Miller CH, Pittadaki J. Comparison of the
availability and content of genetic counseling as
perceived by hemophilic men and carriers in the U.S.A.,
Canada, Scotland, and Greece. American Journal of
Medical Genetics 24: 7-21, 1986.
14. Miller CH, Hilgartner MW, Harris MB, Bussel
JB, Aledort LM. Concurrence of von Willebrand's disease
and hemophilia A: implications for carrier detection
and prevalence. American Journal of Medical Genetics
24: 83-94, 1986.
15. Miller CH, Hilgartner MW, Aledort LM.
Reproductive choices in hemophilic men and carriers.
American Journal of Medical Genetics 26: 591-598, 1987.
16. Orstavik KH, Miller CH. IgG subclass
identification of inhibitors to Factor IX in haemophilia
B patients. British Journal of Haematology 68:
451-454, 1988.
17. Driscoll MC, Dispenzieri A, Tobias E, Miller
CH, Aledort LM. A second BamHI polymorphism and
haplotype association in the factor IX gene. Blood 72:
61-65, 1988.
18. Keppen LD, Fasules JW, Burks AW, Gollin SM,
Sawyer JR, Miller CH. Confirmation of autosomal
dominant transmission of the DiGeorge malformation
complex. Journal of Pediatrics 113: 506-508, 1988.
19. Kletzel M, Miller CH, Becton DL, Chadduck WM,
Elser JM. Post delivery head bleeding in hemophilic
neonates: causes and management. American Journal of
Diseases of Children 143: 1107-1110, 1989.
19a. Kletzel M, Miller CH, Becton DL, Chadduck WM,
Elser JM. Hemorragies craniennes la naissance chez les
enfants hemophiles: causes et traitement. American
Journal of Diseases of Children (French edition) 8:
353-357, 1989.
20. Miller CH, O'Brien TJ, Chatelain S, Butler BB,
Quirk JG. Alteration of age-specific risk for
chromosomal trisomies by maternal serum
alpha-fetoprotein and human chorionic gonadotropin
screening. Prenatal Diagnosis 11: 153-158, 1991.
21. Kletzel M, Elser J, Miller CH, Shock N, Whaley
PK. Pancreatitis in HIV-positive hemophiliacs. AIDS
Patient Care 5: 280-281, 1991.
22. Hassed SJ, Miller CH, Pope SK, Murphy P, Quirk
JG, Cunniff C. Perinatal lethal conditions: the effect
of diagnosis on decision making. Obstetrics &
Gynecology 82: 37-42, 1993.
23. Hurley TJ, Miller C, O’Brien TJ, Blacklaw M,
Quirk JG. Maternal serum human chorionic gonadotropin
as a marker for delivery of low-birth-weight infants in
women with unexplained elevations in maternal serum
alpha-fetoprotein. Journal of Maternal-Fetal Medicine
5:340-344, 1996.
24. DiMichele DM, Lasak ME, Miller CH. In vitro
factor VIII recovery during the delivery of ultra-pure
factor VIII concentrate by continuous infusion.
American Journal of Hematology 51:99-103, 1996.
25. Miller CH, Kelley L, Green D. Diagnosis of von
Willebrand disease Type 2N: a simplified method for
measurement of factor VIII binding to von Willebrand
factor. American Journal of Hematology 58:311-318,
1998.
26. Dilley A, Drews C, Miller C, Lally C, Austin
H, Ramaswamy D, Lurye D, Evatt B. Von Willebrand
disease and other inherited bleeding disorders in women
with diagnosed menorrhagia. Obstetrics & Gynecology
97:630-636, 2001.
27. Miller CH, Dilley A, Richardson L, Hooper WC,
Evatt BL. Population differences in von Willebrand
factor levels affect the diagnosis of von Willebrand
disease in African-American women. American Journal of
Hematology 67:125-129, 2001.
28. Dilley A, Benito C, Hooper WC, Austin H,
Miller C, El-Jamil M, Cottrell S, Benson J, Evatt BL,
Patterson-Barnett A, Eller D, Philipp C. Mutations in
the factor V, prothrombin and MTHFR genes are not risk
factors for recurrent fetal loss. Journal of
Maternal-Fetal and Neonatal Medicine 11: 176-182, 2002.
29. Miller CH, Platt SJ, Daniele C, Kaczor D.
Evaluation of two automated methods for measurement of
the ristocetin cofactor activity of von Willebrand
factor. Thrombosis and Haemostasis 88:56-59, 2002.
30. Miller CH, Dilley AB, Drews Carolyn,
Richardson L, Evatt B. Changes in von Willebrand factor
and factor VIII levels during the menstrual cycle.
Letter to the Editor. Thrombosis and Haemostasis 87:
1082-1083, 2002.
31. Philipp CS, Dilley A, Miller CH, Evatt B,
Baranwal A, Schwartz R, Bachmann G, Saidi P. Platelet
functional defects in women with unexplained
menorrhagia. Journal of Thrombosis and Haemostasis 1:
477-484.
32. Miller CH, Haff E, Platt SJ, Rawlins P, Drew
CD, Dilley AB, Evatt B. Measurement of von Willebrand
factor activity: relative effects of ABO blood type and
race. Submitted.
Book Chapters
1. Miller CH, Hilgartner MW. Genetic Disorders
of Hemostasis. In Genetic Diseases and Pregnancy:
Maternal Effects and Fetal Outcome, Simpson JL, Schulman
JD, eds. New York: Academic Press, pp 123-168, 1981.
2. Miller CH. Genetics of Hemophilia and Von
Willebrand's Disease. In Hemophilia in Children and
Adults, Hilgartner MW, ed. New York: Masson Publishing
Co., pp 29-62, 1982.
3. Miller CH. Genetic Counseling in
Comprehensive Care. In Hemophilia in Children and
Adults, Hilgartner MW, ed. New York: Masson Publishing
Co.,
pp 211-217, 1982.
4. Miller CH. Genetic Counseling in
Hemophilia. In Hemophilia in the Child and Adult,
Hilgartner MW, Pochedly C, eds. New York: Raven Press,
pp 161-172, 1989.
5. Miller CH. Genetics of Hemophilia and von
Willebrand's Disease. In Hemophilia in the Child and
Adult, Hilgartner MW, Pochedly C, eds. New York: Raven
Press, pp 297-345, 1989.
Other Publications
Miller
CH. The Inheritance of Hemophilia. A publication of the
National Hemophilia Foundation, 1980. Revised editions,
1986, 1992, 1996, 1999.
